Indiana University is a major public University with over 95,000 students located on nine campuses throughout the State of Indiana. The Indiana University School of Medicine (IUSM) has the highest enrollment of any medical school in the country and is the only allopathic medical school in the State of Indiana. The School of Medicine is located on an urban 85-acre campus known as Indiana University Purdue University in Indianapolis (IUPUI) located 1 mile from the center of Indianapolis, a city of 1.6 million residents, and the largest metropolitan area in the State. IUPUI is a center for undergraduate education and home to professional schools for health and rehabilitation services, business, dentistry, law, medicine and nursing.

Hospitals staffed by IUSM teaching faculty provide a broad array of clinical and research opportunities for faculty and students and serve as the major referral source for citizens in the State of Indiana. These facilities include: Sidney and Lois Eskenazi Hospitall, Roudebush VA Medical Center, LaRue Carter Psychiatric Hospital, Riley Hospital for Children, and Indiana University Hospital.  Methodist Hospital is approximately 2 miles from the main IUMC campus and is easily accessed by faculty and students by a monorail connecting the two campuses.

As a Public Medical School, the School of Medicine has a long tradition of fulfilling it's responsibility of providing students with the opportunity to acquire a sound education in medicine, providing comprehensive health care to the citizens of the State, and providing graduate education in order to produce practitioners through clinical residency and fellowship programs. In addition, the School of Medicine has historically had pockets of excellence in both the basic science as well as the clinical departments allowing superb training of basic scientists and physician scientists in selected areas (see core interdisciplinary areas of training). Faculty and their trainees have made a range of scientific contributions to health care including major advances in cancer therapeutics, stem cell transplantation, echocardiography, diabetes, medical informatics, and biomedical engineering. The importance of these contributions are exemplified in part by the recognition of 6 faculty members being inducted into the Institute of Medicine, including three within the last 5 years.

In the past 10 years the School of Medicine has systematically embraced a goal to become a leader and collaborator in basic and translational medical science innovation with institutions in Indiana and nationally. There has been a marked expansion of the basic science programs within the School of Medicine; an increase in the recruitment of physician scientists, and an increased opportunity for collaborative interactions to facilitate the translation of basic science research to the clinic.

Consequently, there has been a major expansion of research faculty and space, as well as an increased emphasis in the programmatic training of basic scientists and physician-scientists. This increase in activity has occurred not only by increased interactions between the basic scientist and physician-scientists at IUSM, but has also taken advantage of the local strengths in nanotechnology, biomedical monitoring, and tissue engineering within the Weldon School of Biomedical Engineering at Purdue University, one of the premier institutions in engineering. Additionally, the Departments of Analytical Chemistry at IU Bloomington and at Purdue University have tremendous depth in proteomics, and the faculty within the School of Medicine both collaborate and share combined research facilities located in Indianapolis with those faculties.

Finally, Central Indiana is the headquarters of a rapidly growing mixture of established pharmaceutical, new biotechnology companies, and medical device companies including, Eli Lilly, Dow Agrosciences, Cooke, Endocyte, and Guidant Corporation. A forum known as Biocrossroads, a cooperative entity composed of collaborations between Indiana University, Purdue University, the regional life sciences companies, and the Indiana Health Forum, with support from the City of Indianapolis and Eli Lilly, facilitates interactions between investigators at the medical center and these groups.